CestoNex-N (Niclosemide Powder)
Cestonex-N is anthelmintic Niclosamide Veterinary Oral Powder B.P. Vet, is active against tapeworms and intestinal flukes such as paramphistomum in ruminants.
Cestonex-N inhibits phosphorylation in the mitochondria of cestodes. Both in vitro and in vivo, the scolex and proximal segments are killed on contact with the drug. The loosened scolex may be digested in the intestine; hence, it may be impossible to identify the scolex in the feces. Cestonex-N is taenicidal in action and eliminates not only the segments but also scolex.
Cestonex-N activity against the worms appears to be due to inhibition of mitochondrial oxidative phosphorylation; anaerobic ATP production is also affected.
The cestocidal activity of Cestonex-N is due to the inhibition of absorption of glucose by the tapeworm and to the uncoupling of the oxidative phosphorylation process in the mitochondria of cestodes. The accumulated lactic acid resulting from the blocking of Kerbs cycle kills the worms.
Cestonex-N is indicated in both tapeworm infestation of Livestock, Poultry, Dogs and Cats and also in immature paramphistomiasis (Amphistomiasis) of Cattle, Sheep and Goats.
Each gram contains:
Niclosamide I.P. : 750 mg
Administation and dosage:
Cestonex-N dispersible powder may be administered as a drench, in feed or as such.
Cattle and Horses 1 gm for 15 kg body weight
Sheep and Goats 1 gm for 10 kg body weight
Dogs and Cats 1 gm for 7.5 kg body weight(130 mg per kg body weight)
Poultry 1 gm for 5 adult birds(Approx. 175 mg per kg body Weight)
Cattle, Sheep & Goats:
Higher dosage at the rate of 120 mg/kg body weight is recommended. Therefore 3 gm of Cestonex-N may be given to an animal weighing 25 kg.
50 gm and 100 gm.